The rapid growth of urbanization, the crisis of natural resources, and the consequences of climate change have intensified the need to identify and implement innovative approaches to urban management. Biophilic design, as an approach based on the structural and functional connection between humans and nature, can—through the application of indicators such as natural light, natural ventilation, native vegetation, the presence of water elements, and biomimetic patterns—positively influence energy reduction, water-use optimization, biodiversity enhancement, air quality improvement, and citizens’ mental well-being. This study aims to define a theoretical–practical framework for integrating biophilic design and urban resource management using a descriptive–analytical method, a systematic review of scientific literature, and a comparative analysis of domestic and international case studies. The findings indicate that the purposeful overlap of biophilic design principles with resource management strategies not only enhances environmental performance and optimizes resource consumption but can also serve as a practical pathway toward sustainable development and increased resilience in metropolitan areas.